Mucuna Pruriens Extract Levodopa 98%
|FOB Unit Price:||US $1 US $100|
|Purchase Qty. (KG)||FOB Unit Price|
|Transport Package:||Aluminum Foil Vacuum Bag/ Drum|
|Payment Terms:||L/C, T/T, Paypal, Western Union, STS/ESCROW|
- Model NO.: 59-92-7
- Name: Levodopa
- Purity: 98%
- Trademark: CPE
- Origin: Nanjing, China
- Raw Material: Plants
- Appearance: White Powder
- Test Method: HPLC
- Specification: ISO. SGS. BV
- HS Code: 2932999099
Gray white powder
Seed of Mucuna macrocarpa Wall
2 years when properly stored.
Cool and dry place,keep away from strong light & high temp
25kg or 30kg/drum,or as per your requests.
Insoluble in water,soluble in ethanol, no extraneous substance after being dissolved.
Levodopa is used to increase dopamine levels for the treatment of Parkinson's disease and dopamine-responsive dystonia, since it is able to cross the blood-brain barrier, whereas dopamine itself cannot. Once levodopa has entered the central nervous system (CNS), it is metabolized to dopamine by aromatic L-amino acid decarboxylase. Pyridoxal phosphate (vitamin B6) is a required cofactor for this decarboxylation, and may be administered along with levodopa, usually as pyridoxine.
Conversion to dopamine also occurs in the peripheral tissues, i.e., outside the brain. This may be the mechanism of the adverse effects of levodopa, listed below. It is standard clinical practice to co-administer a peripheral DOPA decarboxylase inhibitor,carbidopa or benserazide,and often a catechol-O-methyl transferase (COMT) inhibitor, like entacapone, to prevent synthesis of dopamine in peripheral tissue. Co-administration of pyridoxine without a decarboxylase inhibitor accelerates the extracerebral decarboxylation to such an extent that it cancels out the effects of levodopa administration, a circumstance that historically caused great confusion.
L-DOPA (3,4-dihydroxy-L-phenylalanine) is a naturally occurring amino acid found in food and made from L-Tyrosine in the human body. L-DOPA is converted into dopamine in the brain and body. It is sold as a dietary supplement and as a prescription drug in the US. In clinical use, Levodopa (INN) is administered in the management of Parkinson's disease and dopa-responsive dystonia. It is also used as a component in marine adhesives used by pelagic life.